解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::HMG-CoA reductase (HMGCR) is an enzyme involved in cholesterol synthesis. To investigate the contribution of the HMGCR gene to lipids and lipoprotein subfractions in different ethnicities, we performed an association study in the Multi-Ethnic Study of Atherosclerosis (MESA). In total, 2,444 MESA subjects [597 African-...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-009-3314-6
更新日期:2009-08-01 00:00:00
abstract::This study was designed to determine the nutritional lipid requirement of Manchurian trout and to investigate the effects of lipid concentrations on the antioxidant status in larvae with experimental diets with different lipid levels. Oxidative stress differences between different organs and tissues were also assessed...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-009-3313-7
更新日期:2009-07-01 00:00:00
abstract::Palm oil is one of the most important edible oils in the world. Its composition (rich in palmitate and oleate) make it suitable for general food uses but its utility could be increased if its fatty acid quality could be varied. In this study, we have modified a palm olein fraction by transesterification with the n-3 p...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-009-3304-8
更新日期:2009-07-01 00:00:00
abstract::Experimental studies have suggested an important role of the spleen in lipid metabolism, although with controversial results. Our purpose was to analyze the effect of a nutritionally balanced (NB) diet and a diet containing pork fat (PF) as source of lipids on the lipid profile of rats submitted to splenic surgery. Si...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-009-3302-x
更新日期:2009-06-01 00:00:00
abstract::The aim of this study was to determine the fatty acid composition and trans fatty acid and fatty acid contents of breast milk in Turkish women and to find the effect of breastfeeding mothers' diet on trans fatty acid and fatty acid composition. Mature milk samples obtained from 50 Turkish nursing women were analyzed. ...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-009-3293-7
更新日期:2009-05-01 00:00:00
abstract::Oxidized low density lipoprotein (Ox-LDL) is a well-established risk factor in atherosclerosis and lysophosphatidylcholine (LysoPtdCho) is considered to be one of the major atherogenic component of Ox-LDL. The purpose of this work was to investigate the effects of two membrane n-3 long chain polyunsaturated fatty acid...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-009-3284-8
更新日期:2009-03-01 00:00:00
abstract::Many reports have shown the beneficial effects of consumption of pine seeds and pine seed oil. However, few studies have examined the biological effect of pinolenic acid (PNA; 5,9,12-18:3), the main fatty acid in pine seed oil. In this study, using murine macrophage RAW264.7 cells as a model, we examined the effect of...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-008-3276-0
更新日期:2009-03-01 00:00:00
abstract::Ceramides are the major type of lipid found in stratum corneum from the skin, gingiva and hard palate. The present study examined the ceramides of the stratum corneum from the hard palate. Six fractions of ceramides were isolated by preparative thin-layer chromatography. The least polar fraction contained an unusual a...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-009-3283-9
更新日期:2009-03-01 00:00:00
abstract::Membrane lipids of photosynthetic organisms consist of glycerophospholipids and glyceroglycolipids. We investigated a method for the simultaneous quantitative analysis of neutral and acidic lipids using HPLC-ELSD, and quantified monogalactosyldiacylglycerol (MGDG), digalactosyldiacylglycerol (DGDG) and sulfoquinovosyl...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-008-3248-4
更新日期:2009-01-01 00:00:00
abstract::Cholesterol itself has very few structural/chemical features suitable for real-time imaging in living cells. Thus, the advent of dehydroergosterol [ergosta-5,7,9(11),22-tetraen-3beta-ol, DHE] the fluorescent sterol most structurally and functionally similar to cholesterol to date, has proven to be a major asset for re...
journal_title:Lipids
pub_type: 杂志文章,评审
doi:10.1007/s11745-008-3194-1
更新日期:2008-12-01 00:00:00
abstract::Mitochondrial cytochrome P450 enzymes (CYP or P450, EC 1.14.13.15) play an important role in metabolism of cholesterol. CYP27A1 hydroxylates cholesterol at position 27 and, thus, initiates cholesterol removal from many extrahepatic tissues. CYP11A1 is a steroidogenic P450 that converts cholesterol to pregnenolone, the...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-008-3234-x
更新日期:2008-12-01 00:00:00
abstract::Glucose-sensitive liposomes were prepared by incorporating hydrophobically modified glucose oxidase (EC 1.1.3.4.) into the liposomal bilayer of dioleoylphosphatidylethanolamine and cholesteryl hemisuccinate. For the release test, calcein, a fluorescence marker, was entrapped in the liposomes. The liposomes were stable...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-008-3223-0
更新日期:2008-10-01 00:00:00
abstract::An important enzyme involved in phospholipid turnover is the acyl-CoA: lysophosphatidylcholine acyltransferase (LPCAT). Here, we report characterization of a newly discovered human LPCAT (LPCAT3), which has distinct substrate preferences strikingly consistent with a role in phosphatidylcholine (PtdCho) remodeling and ...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-008-3233-y
更新日期:2008-10-01 00:00:00
abstract::Synthetic activators of peroxisome proliferator-activated receptors (PPAR)-alpha and -gamma are capable of reducing macrophage foam cell cholesterol accumulation through the activation of genes involved in cholesterol homeostasis. Since conjugated linoleic acids (CLA) were also demonstrated to activate PPARalpha and P...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-008-3226-x
更新日期:2008-10-01 00:00:00
abstract::Peroxisome proliferator-activated receptor alpha (PPARalpha) belongs to the nuclear receptor superfamily that regulates multiple target genes involved in lipid metabolism. Cholesterol ester transfer protein (CETP) is a secreted glycoprotein that modifies high-density lipoprotein (HDL) particles. In humans, plasma CETP...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-008-3187-0
更新日期:2008-07-01 00:00:00
abstract::The present study determined alpha-tocopherol mass transfer from an alpha-tocopherol-rich emulsion to LDL and HDL, and assessed the potential of different mechanisms to modulate alpha-tocopherol transfers. Emulsion particles rich in alpha-tocopherol were incubated in vitro with physiological concentrations of LDL or H...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-008-3184-3
更新日期:2008-07-01 00:00:00
abstract::The formation of hydroxy radicals, hexanal, and 2,4-decadienal was demonstrated from the autocatalytic dimer peroxide which had been reported by us in autoxidizing linoleate (Morita and Tokita in Lipids 41:91-95, 2006). Then, autoxidizing linoleate containing eleostearate was investigated for new autocatalytic substan...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-008-3170-9
更新日期:2008-07-01 00:00:00
abstract::This study examined the effects of five CLA isomers and the non-conjugated LA on nitric oxide (NO) production, an important modulator of vasodilation, inflammation, and cytotoxicity. Bovine aortic endothelial cells (BAECs) were pretreated with pure CLAs (c9, c11-, c9, t11-, t9, t11-, t10, c12-, c11, c13-CLA) and the n...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-008-3160-y
更新日期:2008-04-01 00:00:00
abstract::Subjects with echolucent carotid plaques have an increased risk of ischemic cerebrovascular events independent of degree of stenosis. Low plasma lipoprotein lipase (LPL) activity promotes a proatherogenic lipid profile, and delayed chylomicron clearance is a risk factor for atherosclerosis. This study was conducted to...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-008-3159-4
更新日期:2008-04-01 00:00:00
abstract::Changes of lipoprotein composition have been mainly reported in conditions of sepsis. This study characterized compositional changes in LDL and HDL during the acute phase response following cardiac surgery with cardiopulmonary bypass. Twenty-one patients undergoing cardiac surgery were included in this study. Blood sa...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-007-3114-9
更新日期:2007-12-01 00:00:00
abstract::Enrichment of beef muscle with n-3 fatty acids (FA) is one means to introduce these FA into the diet, but ruminal biohydrogenation limits their bioavailability. To address this problem, we evaluated the ability of condensed tannin (quebracho), in the presence or absence of casein, to protect 18:3n-3 in flaxseed from h...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-007-3126-5
更新日期:2007-12-01 00:00:00
abstract::The aim of the present study was to identify the effects of dehydroepiandrosterone (DHEA) on hepatic lipid metabolism parameters and lipogenic gene mRNA expression in broiler chickens. A total of 72 1-day-old broiler chicks received a common basal diet with DHEA added at either 0 (control), 5 or 20 mg/kg feed. In the ...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-007-3104-y
更新日期:2007-11-01 00:00:00
abstract::Postprandial chylomicrons are potent ultimate acceptors of cell membrane cholesterol and are believed to accelerate reverse cholesterol transport (RCT). We compared the effects of meals rich in polyunsaturated fat (PUFA) and either high (605 mg) or low (151 mg) in cholesterol and a meal rich in dairy fat (DF) in the f...
journal_title:Lipids
pub_type: 杂志文章,随机对照试验
doi:10.1007/s11745-007-3101-1
更新日期:2007-10-01 00:00:00
abstract::Oxidized LDL (oxLDL) has been shown to activate the sphingomyelinase pathway producing ceramide in vascular smooth muscle cells. Therefore ceramide, which is a biologically active lipid causing apoptosis in a variety of cells, may be involved in the apoptotic action of oxLDL. In this study, we examined whether cholest...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-007-3067-z
更新日期:2007-10-01 00:00:00
abstract::This review explores the effects of dietary long chain polyunsaturated fatty acids (LCPUFA) on various aspects of early immune development and their potential role in the development or the prevention of immune disease. Modern diets have become increasingly rich in n-6 LCPUFA and relatively n-3 LCPUFA deficient. These...
journal_title:Lipids
pub_type: 杂志文章,评审
doi:10.1007/s11745-007-3030-z
更新日期:2007-09-01 00:00:00
abstract::The recent discovery that the fatty acid composition of tissue phospholipids varies in a systematic manner among species has lead to the proposal that membrane fatty acid composition is an important determinant of the metabolic rate characteristic for each species. Endotherms (mammals and birds) have a basal metabolic...
journal_title:Lipids
pub_type: 杂志文章,评审
doi:10.1007/s11745-007-3058-0
更新日期:2007-09-01 00:00:00
abstract::The total lipid content, composition of main lipid classes, composition of sterols and composition of fatty acids in the main glycerolipids of Perna viridis were analyzed through four seasons using TLC-FID and GLC. Mussel samples were collected during different seasons between 2003 and 2004 from Shengsi Island, Zhejia...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-007-3078-9
更新日期:2007-08-01 00:00:00
abstract::The term "conjugated linoleic acid" (CLA) refers to a group of positional and geometric isomers that are derived from linoleic acid and are found primarily in meat and milk products from ruminant animals. Due to the array of putative benefits associated with various forms of CLA, there has been recent interest in supp...
journal_title:Lipids
pub_type: 杂志文章,随机对照试验
doi:10.1007/s11745-007-3087-8
更新日期:2007-08-01 00:00:00
abstract::The evaluation of antioxidant activity in vivo is difficult. In this study, the effects of dietary natural and synthetic antioxidants on the lipid peroxidation in mice were assessed using a biomarker, total hydroxyoctadecadienoic acid (tHODE). Biological samples such as plasma, erythrocytes, and tissues were first red...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-007-3043-7
更新日期:2007-05-01 00:00:00
abstract::Alteration of lipid constituents of cellular membranes has been proposed as a possible mechanism for cancer promotion by fumonisin B(1 )(FB(1)). To further investigate this hypothesis a dietary dosage which initiates and promotes liver cancer (250 mg FB(1)/kg) was fed to male Fischer rats for 21 days and the lipid com...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-007-3025-9
更新日期:2007-04-01 00:00:00
abstract::The lipid quality of ruminant products is largely determined by the extent of rumen microbial biohydrogenation (BH) of polyunsaturated fatty acids (FAs) and the substances formed thereby. In vitro batch incubations with mixed rumen bacteria were tracked over 24 h to characterize the profiles and kinetics of the BH pro...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-007-3032-x
更新日期:2007-04-01 00:00:00
abstract::Apolipoprotein (apoB) plays a fundamental role in the transport and metabolism of plasma triacylglycerols (TAGs) and cholesterol. Several apoB polymorphic sites have been studied for their potential use as markers for coronary heart disease in the population. In view of the importance of apoB in postprandial metabolis...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-007-3027-7
更新日期:2007-03-01 00:00:00
abstract::Sterols, which are biosynthesized via the cytoplasmic mevalonate (MVA) pathway, are important structural components of the plasma membrane and precursors of steroid hormones in both vertebrates and plants. Ergosterol and cholesterol are the major sterols in yeast and vertebrates, respectively. In contrast, plants prod...
journal_title:Lipids
pub_type: 杂志文章,评审
doi:10.1007/s11745-006-1000-5
更新日期:2007-02-01 00:00:00
abstract::Flaxseed derivatives, including both oil and flax lignan, modify progression of renal injury in animal models, including Han:SPRD-cy polycystic kidney disease (PKD). Gender is a significant factor in the rates of progression of many forms of human renal disease, but the role of gender in the response to nutrition inte...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-006-5064-z
更新日期:2006-12-01 00:00:00
abstract::This study reports the cloning, functional characterization, tissue expression, and nutritional regulation of a delta6 fatty acyl desaturase of Atlantic cod (Gadus morhua). PCR primers were designed based on the sequences of conserved motifs in available fish desaturases and used to isolate a cDNA fragment from cod li...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-006-5051-4
更新日期:2006-11-01 00:00:00
abstract::One of the main biological systems that can be used as a model for studying the molecular mechanisms involved in membrane fusion is the formation of the nuclear envelope (NE). NE assembly to form the male pronucleus at fertilization occurs by binding of NE membrane precursor vesicles to chromatin and their fusion. MV1...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-006-5045-2
更新日期:2006-10-01 00:00:00
abstract::In humans and animals, intestinal flora is indispensable for bile acid transformation. The goal of our study was to establish gnotobiotic mice with intestinal bacteria of human origin in order to examine the role of intestinal bacteria in the transformation of bile acids in vivo using the technique of gnotobiology. Ei...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-006-5038-1
更新日期:2006-09-01 00:00:00
abstract::trans-10,cis-12-CLA (t10,c12-CLA) inhibits lipid deposition in adipose tissue of many species, but it also enhances lipid deposition in liver. We evaluated effects of dietary t10,c12-CLA content and gender on carcass composition, FA profile of selected tissues, and expression of FA synthase (FAS) and stearoyl-CoA desa...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-006-5029-2
更新日期:2006-08-01 00:00:00
abstract::Dyslipoproteinemia of the Nagase analbuminemic rat (NAR) is characterized by elevated concentrations of VLDL and LDL attributed to increased rates of liver lipoprotein synthesis. Increased lysophosphatidylcholine (LPC) in NAR HDL has been attributed to high plasma LCAT activity. We show here that, as compared with Spr...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-006-5017-6
更新日期:2006-07-01 00:00:00
abstract::A mutant of Mortierella alpina, JT-180, which is defective in its delta12 desaturase activity but exhibits enhanced activities of delta5 and delta6 desaturases, produced a high proportion (up to 80%) of odd-chain FA when grown on 3% n-heptadecane. Following growth of the mutant on n-heptadecane, three unusual odd-chai...
journal_title:Lipids
pub_type: 杂志文章
doi:10.1007/s11745-006-5011-z
更新日期:2006-06-01 00:00:00